Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13931444 | 0.78 | NPC1 (0.38) | NOTUMKDM4ESMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3496060 | 0.76 | NOTUM (0.64) | NOTUMKDM4ESMN1; SMN2TP53CYP2D6 | |
| SCHEMBL26118857 | 0.74 | KDM4E (0.72) | KDM4ESMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL4273292 | 0.74 | NOTUM (0.52) | NOTUMKDM4EPOLBMAPTAR | |
| SCHEMBL4259902 | 0.74 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL9080467 | 0.72 | HTT (0.65) | NOTUMKDM4ESMN1; SMN2TP53CYP2D6 | |
| SCHEMBL3495559 | 0.71 | CYP19A1 (0.55) | NOTUMKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4257630 | 0.70 | ADORA2A (0.44) | NOTUMKDM4ESMN1; SMN2TP53CYP2D6 | |
| SCHEMBL4267127 | 0.68 | GAA (0.56) | KDM4ESMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL16035644 | 0.66 | NR1H2 (0.69) | KDM4ESMN1; SMN2HTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048258-A1 | Amide Compound | TAKEDA, PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1845081-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048258-A1 | Amide Compound | DLAT, DGAT1, DGAT2 | NOTUM 2828/4885KDM4E 1998/4885SMN1; SMN2 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.