Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934026 | 0.88 | ALDH1A1 (0.65) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL10553079 | 0.85 | CYP2D6 (0.57) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL365344 | 0.84 | TSHR (0.73) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL1734204 | 0.83 | CYP1A2 (0.67) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL10650109 | 0.83 | CYP1A2 (0.67) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL10551995 | 0.82 | DRD2 (0.55) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL4274526 | 0.81 | KCNH2 (0.56) | TSHRSIGMAR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1935375 | 0.81 | TSHR (0.69) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL3724067 | 0.80 | SIGMAR1 (0.61) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 | |
| SCHEMBL10648914 | 0.79 | CYP1A2 (0.74) | TSHRSIGMAR1LMNAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036909-B1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | UNIV BEIJING (CN) | 2016-05-04 | — | — | EP | disclosed |
| US-9133195-B2 | Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof | PEKING UNIVERSITY (CN) | 2015-09-15 | — | — | US | disclosed |
| US-20090325929-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | PEKING UNIVERSITY (CN) | 2009-12-31 | — | — | US | disclosed |
| EP-2036909-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | Peking University (CN) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325929-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | CHRM4, CHRM1, CHRNA4 | TSHR 170/4885SIGMAR1 27/4885LMNA 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.