Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27753546 | 1.00 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL8655504 | 1.00 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28984070 | 0.89 | PPARG (0.52) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4339905 | 0.89 | PPARG (0.52) | LMNAALDH1A1SMN1; SMN2HTTPPARG | |
| SCHEMBL98228 | 0.89 | PPARG (0.52) | LMNAALDH1A1SMN1; SMN2HTTPPARG | |
| SCHEMBL2064222 | 0.89 | PPARG (0.52) | LMNAALDH1A1SMN1; SMN2HTTPPARG | |
| Fumaric Acid SCHEMBL4345636 | 0.88 | LMNA (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL4345633 | 0.88 | LMNA (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL4346408 | 0.88 | LMNA (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Acrylic Acid SCHEMBL28294518 | 0.88 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101098921-A | Use of carbon nanotubes for preparing electrically conductive organic compositions and use of such compositions | ARKEMA FRANCE (FR) | 2008-01-02 | — | — | CN | claimed |
| US-7579300-B2 | Image formation employing the image recording material; thermosensitive printing plate material and an image formation process employing the thermosensitive printing plate material utilized in a computer to plate (CTP) system; excellent on-press developability and printing durability | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2009-08-25 | — | — | US | disclosed |
| CN-101378114-A | Anode and method for manufacturing same, secondary battery and method for manufacturing same | SONY CORP (JP) | 2009-03-04 | — | — | CN | disclosed |
| EP-1886829-A1 | IMAGE RECORDING MATERIAL AND IMAGE FORMING METHOD OF IMAGE RECORDING MATERIAL | Konica Minolta Medical & Graphic, Inc. (JP) | 2008-02-13 | — | — | EP | disclosed |
| EP-1588860-B1 | Printing plate material and printing process | KONICA MINOLTA MED & GRAPHIC (JP) | 2008-01-16 | — | — | EP | disclosed |
| CN-101098921-A | Use of carbon nanotubes for preparing electrically conductive organic compositions and use of such compositions | ARKEMA FRANCE (FR) | 2008-01-02 | — | — | CN | disclosed |
| US-7306897-B2 | Preparation method of printing plate material and printing plate material | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-12-11 | — | — | US | disclosed |
| EP-1852272-A1 | MATERIAL OF LITHOGRAPHIC PRINTING PLATE AND METHOD OF PRINTING | Konica Minolta Medical & Graphic, Inc. (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1609617-B1 | Printing plate material and image formation process | KONICA MINOLTA MED & GRAPHIC (JP) | 2007-10-03 | — | — | EP | disclosed |
| US-7267928-B2 | Printing plate material and printing process | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-09-11 | — | — | US | disclosed |
| US-20050181308-A1 | Preparation method of printing plate material and printing plate material | KONICA MINOLTA MEDICAL & GRAPHIC, INC. | 2005-08-18 | — | — | US | disclosed |
| EP-0916996-B1 | Imaging element comprising an electrically-conductive layer | EASTMAN KODAK CO (US) | 2004-09-01 | — | — | EP | disclosed |
| US-6140030-A | SUPPORT WITH SILVER HALIDE IMAGES SUPERPOSED ON SUPPORTS, TRANSPARENT ELECTROCONDUCTIVE LAYER AND SECOND ELECTROCONDUCTIVE LAYER | EASTMAN KODAK COMPANY (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0916996-A1 | Imaging element comprising an electrically-conductive layer | EASTMAN KODAK COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |
| US-5866287-A | MULTILAYER; SUPPORT, IMAGE FORMING LAYER AND TRANSPARENT ELECTROCONDUCTIVE LAYER | EASTMAN KODAK COMPANY (US) | 1999-02-02 | — | — | US | disclosed |
| US-5827630-A | ANTISTATIC | EASTMAN KODAK COMPANY (US) | 1998-10-27 | — | — | US | disclosed |
| EP-0506309-B1 | Silver halide photographic light-sensitive material | KONISHIROKU PHOTO IND (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0589329-B1 | Antistatic film bases and photographic elements comprising said antistatic film bases | MINNESOTA MINING & MFG (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0589329-A1 | Antistatic film bases and photographic elements comprising said antistatic filmbases | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0486982-A1 | Antistatic film bases and photographic elements comprising said antistatic film bases | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |