Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL4270458 | 1.00 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Maleic Acid SCHEMBL27753546 | 1.00 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28984070 | 0.89 | PPARG (0.52) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4339905 | 0.89 | PPARG (0.52) | LMNAALDH1A1SMN1; SMN2HTTPPARG | |
| SCHEMBL98228 | 0.89 | PPARG (0.52) | LMNAALDH1A1SMN1; SMN2HTTPPARG | |
| SCHEMBL2064222 | 0.89 | PPARG (0.52) | LMNAALDH1A1SMN1; SMN2HTTPPARG | |
| Fumaric Acid SCHEMBL4345636 | 0.88 | LMNA (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL4345633 | 0.88 | LMNA (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL4346408 | 0.88 | LMNA (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Acrylic Acid SCHEMBL28294518 | 0.88 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506309-B1 | Silver halide photographic light-sensitive material | KONISHIROKU PHOTO IND (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0589329-B1 | Antistatic film bases and photographic elements comprising said antistatic film bases | MINNESOTA MINING & MFG (US) | 1997-08-13 | — | — | EP | disclosed |
| US-5604083-A | BLEND OF ELECTROCONDUCTIVE POLYMER AND OXAZOLINE POLYMER | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0589329-A1 | Antistatic film bases and photographic elements comprising said antistatic filmbases | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0486982-A1 | Antistatic film bases and photographic elements comprising said antistatic film bases | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |