Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257406 | 0.93 | HDAC6 (0.43) | OPRK1MAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL4268039 | 0.84 | TACR2 (0.47) | MAPTKMT2ASMN1; SMN2ALDH1A1FAAH | |
| SCHEMBL4257512 | 0.81 | LMNA (0.48) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL4258709 | 0.80 | LMNA (0.46) | MAPK1SMN1; SMN2ALDH1A1LMNAFAAH | |
| SCHEMBL4258527 | 0.78 | MEN1 (0.42) | MAPTKMT2AMAPK1SMN1; SMN2GAA | |
| SCHEMBL5011187 | 0.76 | OTUD7B (0.42) | OPRK1MAPTKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL5011711 | 0.76 | MAPT (0.46) | OPRK1MAPTKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL4272821 | 0.76 | TACR2 (0.40) | ALDH1A1LMNASSTR5EPHX2 | |
| SCHEMBL4263517 | 0.75 | MAPK1 (0.37) | MAPK1SMN1; SMN2GAAALDH1A1LMNA | |
| SCHEMBL4258569 | 0.74 | MMP1 (0.43) | KMT2AMEN1LMNAFAAHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |