Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4271025 | 0.87 | TRPV1 (0.46) | LMNAALDH1A1KDM4EKCNH2SMN1; SMN2 | |
| SCHEMBL4262418 | 0.83 | MEN1 (0.41) | MEN1KMT2ALMNASMN1; SMN2THRB | |
| SCHEMBL4272821 | 0.78 | TACR2 (0.40) | LMNAALDH1A1KDM4ETDP1HDAC11 | |
| SCHEMBL5015097 | 0.78 | ALDH1A1 (0.42) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL4272823 | 0.78 | OPRK1 (0.50) | MEN1KMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL4263514 | 0.77 | HSD11B1 (0.40) | LMNAALDH1A1KDM4EGAAHDAC11 | |
| SCHEMBL4257512 | 0.77 | LMNA (0.48) | MEN1KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL4268039 | 0.76 | TACR2 (0.47) | KMT2AALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL1086484 | 0.75 | MAPT (0.45) | KMT2ALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4258569 | 0.75 | MMP1 (0.43) | MEN1KMT2ALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |