Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL552157 | 0.84 | LMNA (0.51) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL4269459 | 0.81 | TRPA1 (0.41) | ALDH1A1MAPTRAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL6326856 | 0.81 | POLB (0.52) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL31477173 | 0.81 | ALDH1A1 (0.45) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL31343879 | 0.80 | KMT2A (0.51) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL646896 | 0.80 | KMT2A (0.49) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL31477122 | 0.78 | MAPT (0.46) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL31477549 | 0.78 | MAPT (0.46) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL31503074 | 0.78 | ALDH1A1 (0.43) | LMNAALDH1A1POLBTDP1MAPT | |
| SCHEMBL31503063 | 0.78 | ALDH1A1 (0.43) | LMNAALDH1A1POLBTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608717-B2 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080070943-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2008-03-20 | — | — | US | disclosed |
| US-7291736-B2 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1648891-A1 | SULFONYLDIHYDROIMID- AZOPYRIDINONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005010003-A1 | SULFONYLDIHYDROIMID- AZOPYRIDINONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20050020596-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070943-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | LMNA 4217/4885ALDH1A1 1019/4885POLB 4854/4885 |
| US-20050020596-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | LMNA 4217/4885ALDH1A1 1019/4885POLB 4854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.