Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 12/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283767 | 0.81 | HRH3 (0.56) | HRH3SIGMAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL32691106 | 0.80 | CCR6 (0.46) | CCR5SIGMAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13434086 | 0.79 | CCR5 (0.59) | CCR5SIGMAR1ALDH1A1 | |
| SCHEMBL7205238 | 0.79 | CCR5 (0.49) | CCR5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7205236 | 0.79 | CCR5 (0.49) | CCR5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL21120476 | 0.79 | SMN1; SMN2 (0.55) | HRH3SIGMAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7813133 | 0.78 | ENPP2 (0.51) | CCR5SIGMAR1 | |
| Hydrochloric Acid SCHEMBL27382588 | 0.78 | CCR5 (0.43) | CCR5SIGMAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13684267 | 0.78 | L3MBTL1 (0.63) | CCR5SIGMAR1 | |
| SCHEMBL13661448 | 0.78 | SIGMAR1 (0.46) | CCR5HRH3SIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131246-A1 | SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS | ASTELLAS PHARMA INC. (JP) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009131246-A1 | SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS | ASTELLAS PHARMA INC. (JP) | 2009-10-29 | — | — | WO | disclosed |