Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 5/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | AGER | Q15109 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32691106 | 0.94 | CCR6 (0.46) | ENPP2SIGMAR1L3MBTL1PTGDR2CCR5 | |
| SCHEMBL13641301 | 0.88 | SIGMAR1 (0.46) | ENPP2SIGMAR1PTGDR2CCR5CCR6 | |
| SCHEMBL30802298 | 0.88 | SLC6A2 (0.45) | CCR5CCR6PAX8TSHRCHRM3 | |
| SCHEMBL10325504 | 0.88 | SIGMAR1 (0.46) | ENPP2SIGMAR1PTGDR2CCR5CCR6 | |
| SCHEMBL28523905 | 0.87 | ENPP2 (0.51) | ENPP2SIGMAR1L3MBTL1PTGDR2CCR5 | |
| SCHEMBL30802466 | 0.87 | SMN1; SMN2 (0.49) | SIGMAR1CCR5CYP2C19CHRM2CHRM5 | |
| SCHEMBL7801189 | 0.84 | ENPP2 (0.55) | ENPP2SIGMAR1L3MBTL1PTGDR2CCR5 | |
| SCHEMBL27757526 | 0.84 | ENPP2 (0.52) | ENPP2SIGMAR1L3MBTL1PTGDR2CCR5 | |
| SCHEMBL29068551 | 0.84 | ENPP2 (0.52) | ENPP2SIGMAR1L3MBTL1PTGDR2CCR5 | |
| SCHEMBL22285161 | 0.83 | ENPP2 (0.57) | ENPP2SIGMAR1L3MBTL1PTGDR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |