SCHEMBL42761

SCHEMBL42761

Nc1nc2[nH]c(O)nc2c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.53
ALDH1A1 P00352 1/20 0.53
LMNA P02545 1/20 0.53
GLA P06280 1/20 0.53
PMP22 Q01453 1/20 0.53
HSD17B10 Q99714 1/20 0.53
MAPT P10636 1/20 0.46
MITF O75030 1/20 0.44
TP53 P04637 1/20 0.44
THRB P10828 1/20 0.44
ALOX15 P16050 1/20 0.44
HBB P68871 1/20 0.44
HIF1A Q16665 1/20 0.44
DYRK1A Q13627 1/20 0.42
PNP P00491 4/20 0.41
AKR1B1 P15121 4/20 0.39
PIK3CG P48736 1/20 0.38
CDK1 P06493 1/20 0.37
CDK4 P11802 1/20 0.37
CDK2 P24941 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Aminoguanine SCHEMBL5513816 0.96 KDM4E (0.50) KDM4EALDH1A1LMNAGLAPMP22
8-Aminoguanine SCHEMBL21760 0.83 KDM4E (0.60) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL9115 0.76 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL160586 0.76 ALDH1A1 (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL159447 0.76 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL158423 0.76 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL844206 0.76 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL2206472 0.76 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL6686385 0.76 KDM4E (0.53) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL843931 0.76 LMNA (0.53) KDM4EALDH1A1LMNAGLAPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5357 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630827-B2 Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies ROGCON, INC. (US) 2026-05-19 US claimed
US-20250295658-A1 ANTIPARASITIC AGENTS AND METHODS WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH 2025-09-25 US claimed
US-20250257360-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER UNIV OKLAHOMA (US) 2025-08-14 US claimed
CN-113151261-B Antisense oligonucleotides as inhibitors of TGF-R signaling 神经视觉医药有限公司 2025-06-17 CN claimed
US-20250179503-A1 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-06-05 US claimed
CN-120041445-A Ribozyme for specifically regulating gene expression and vector and application thereof 湖南大学 2025-05-27 CN claimed
US-20250146073-A1 METHODS FOR THE TREATMENT OF SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-05-08 US claimed
EP-4549577-A1 NOVEL INDUCED CYTOPLASMIC IVT (ICIVT)-LIKE COMPOSITION AND THE RELATED VACCINE MEDICINE DESIGNS THEREOF Mello Biotech Taiwan Co., Ltd. (TW) 2025-05-07 EP claimed
US-20250115932-A1 INDUCED CYTOPLASMIC IVT (ICIVT)-LIKE COMPOSITION AND THE RELATED VACCINE MEDICINE DESIGNS THEREOF MELLO BIOTECH TAIWAN CO., LTD. (TW) 2025-04-10 US claimed
EP-4504945-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2025-02-12 EP claimed
US-5552285-A DIAGNOSIS AND MONITORING OF INFLAMMATORY AND AUTOIMMUNE DISEASES NEW YORK UNIVERSITY (US) 1996-09-03 US claimed
EP-0706581-A1 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1996-04-17 EP claimed
US-5386030-A Chemical intermediates INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCE OF THE CZECH REPUBLIC (CZ) 1995-01-31 US claimed
EP-0630381-A4 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES. 1995-01-04 EP claimed
EP-0630381-A1 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES. ACAD OF SCIENCE CZECH REPUBLIC (CS) 1994-12-28 EP claimed
WO-1994025626-A1 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1994-11-10 WO claimed
US-5208221-A Nucleotides and intermediates for herpes virus or leukemia virus BRISTOL-MYERS SQUIBB COMPANY (US) 1993-05-04 US claimed
WO-1993007157-A1 ANTIVIRAL ACYCLIC PHOSPHONOMETHOXYALKYL SUBSTITUTED, ALKENYL AND ALKYNYL PURINE AND PYRIMIDINE DERIVATIVES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OFTHE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1993-04-15 WO claimed
WO-1992015707-A1 IMMUNOASSAY FOR ANTIBODIES TO OXIDIZED DNA AND USES THEREOF NEW YORK UNIVERSITY (US) 1992-09-17 WO claimed
EP-0269947-A1 Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1988-06-08 EP claimed