Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 0.80 |
| ▸ | RAB9A | P51151 | 3/20 | 0.80 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.80 |
| ▸ | PKM | P14618 | 2/20 | 0.80 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.80 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.79 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.79 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.79 |
| ▸ | GABRP | O00591 | 3/20 | 0.79 |
| ▸ | GABRD | O14764 | 3/20 | 0.79 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.79 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.79 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 6-Hydroxyflavone SCHEMBL676594 | 0.89 | MAPT (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| 6-Hydroxyflavone SCHEMBL29628861 | 0.89 | MAPT (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL7207188 | 0.88 | CYP3A4 (0.79) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL5424662 | 0.88 | CYP3A4 (0.79) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL311580 | 0.88 | TNKS (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL29677954 | 0.88 | TNKS (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL31675776 | 0.88 | CYP3A4 (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL3135989 | 0.88 | CYP3A4 (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL29384142 | 0.88 | TNKS (1.00) | MAPTCYP3A4HPGDTP53ALDH1A1 | |
| SCHEMBL4981350 | 0.86 | MAPT (0.76) | MAPTCYP3A4HPGDTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | claimed |
| JP-2003504327-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | claimed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | claimed |
| US-10398760-B2 | Method of treating pain using agents that promote neuronal differentiation | RUSANESCU GABRIEL (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180000897-A1 | Method of treating pain using agents that promote neuronal differentiation | RUSANESCU GABRIEL (US) | 2018-01-04 | — | — | US | disclosed |
| EP-2730431-B1 | Rubber composition and tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2017-06-28 | — | — | EP | disclosed |
| US-20140135433-A1 | TIRE WITH RUBBER CONTAINING FLAVONE | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2014-05-15 | — | — | US | disclosed |
| EP-2730431-A1 | Rubber composition and tire with rubber containing flavone | The Goodyear Tire & Rubber Company (US) | 2014-05-14 | — | — | EP | disclosed |
| EP-2277595-A2 | Compounds for immunopotentiation | Novartis Vaccines and Diagnostics, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100226931-A1 | Compounds for immunopotentiation | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-09-09 | — | — | US | disclosed |
| US-20100226931-A1 | Compounds for immunopotentiation | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-09-09 | — | — | US | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1391327-A1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2003057210-A1 | COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| US-20030125264-A1 | Methods For Treating Wounds | KIMBERLY-CLARK WORLDWIDE, INC. | 2003-07-03 | — | — | US | disclosed |
| US-6555523-B1 | Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus | CASCADE ESTATES LTD. (MU) | 2003-04-29 | — | — | US | disclosed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | MAPT 4566/4885CYP3A4 17/4885HPGD 1949/4885 |
| US-20100226931-A1 | Compounds for immunopotentiation | LY96, ICOS, PDCD1 | MAPT 3668/4885CYP3A4 1055/4885HPGD 2336/4885 |
| US-20030125264-A1 | Methods For Treating Wounds | FGF2, MMP1, FIBP | MAPT 4313/4885CYP3A4 3010/4885HPGD 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.