Water

Water

SCHEMBL427934

CC(C)OC(=O)OC(C)(C)C.O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC6 known ✓ Q9UBN7 2/20 0.32
HDAC1 known ✓ Q13547 1/20 0.32
HDAC2 known ✓ Q92769 1/20 0.32
TSHR P16473 1/20 0.42
ELANE P08246 1/20 0.35
DGAT1 O75907 1/20 0.34
CA1 P00915 4/20 0.34
CA2 P00918 4/20 0.34
CA7 P43166 4/20 0.34
HCAR2 Q8TDS4 1/20 0.33
CTSK P43235 4/20 0.33
CTSS P25774 3/20 0.33
CA12 O43570 4/20 0.32
CA14 Q9ULX7 4/20 0.32
CTSL P07711 1/20 0.31
CTSB P07858 1/20 0.31
CYP2D6 P10635 1/20 0.31
CA9 Q16790 3/20 0.30
LMNA P02545 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3082211 0.97 TSHR (0.43) TSHRELANEDGAT1CA1CA2
Hydrogen Peroxide SCHEMBL22069984 0.95 TSHR (0.42) TSHRELANEDGAT1CA1CA2
SCHEMBL29021409 0.86 TSHR (0.39) TSHRELANEDGAT1CA1CA2
SCHEMBL18410854 0.86 TSHR (0.39) TSHRELANEDGAT1CA1CA2
SCHEMBL14593926 0.82 ELANE (0.36) TSHRELANEDGAT1CA1CA2
SCHEMBL28184447 0.80 TSHR (0.31) TSHRCA1CA2CA7
SCHEMBL18636468 0.80 TSHR (0.42) TSHRCA1CA2CA7HCAR2
SCHEMBL6009039 0.80 ELANE (0.35) TSHRELANEDGAT1CA1CA2
SCHEMBL4958194 0.80 ELANE (0.35) TSHRELANEDGAT1CA1CA2
SCHEMBL15424713 0.79 ELANE (0.32) ELANEDGAT1CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114341237-A Polypropylene resin foamed particles, process for producing the same, and polypropylene resin foamed molded article 株式会社钟化 2022-04-12 CN disclosed
CN-110430997-B Bonded composite of thermoplastic resin fiber-reinforced composite material and metal member, and method for producing same 株式会社钟化 2021-09-21 CN disclosed
US-8503853-B2 Plastic optical fiber and plastic optical fiber code TORAY INDUSTRIES, INC. (JP) 2013-08-06 US disclosed
EP-2416189-B1 PLASTIC OPTICAL FIBER AND PLASTIC OPTICAL FIBER CODE TORAY INDUSTRIES (JP) 2013-07-17 EP disclosed
US-8138287-B2 (Meth)acrylate copolymer for syrup and resin composition thereof IDEMITSU KOSAN CO., LTD. (JP) 2012-03-20 US disclosed
EP-2416189-A1 PLASTIC OPTICAL FIBER AND PLASTIC OPTICAL FIBER CODE Toray Industries, Inc. (JP) 2012-02-08 EP disclosed
US-20120020637-A1 PLASTIC OPTICAL FIBER AND PLASTIC OPTICAL FIBER CODE TORAY INDUSTRIES, INC. (JP) 2012-01-26 US disclosed
US-20100022733-A1 (METH)ACRYLATE COPOLYMER FOR SYRUP AND RESIN COMPOSITION THEREOF IDEMITSU KOSAN CO., LTD. (JP) 2010-01-28 US disclosed
EP-2088164-A1 (METH)ACRYLATE COPOLYMER FOR SYRUP AND RESIN COMPOSITION THEREOF Idemitsu Kosan Co., Ltd. (JP) 2009-08-12 EP disclosed
US-6562926-B1 Method for producing water-soluble homopolymers and copolymers, comprising oligoalkylene-imine side chains of the general formula (I), wherein (AI)m, m, Y and x have the definitions given in claim 1, by radical polymerization for BASF AKTIENGESELLSCHAFT (DE) 2003-05-13 US disclosed