Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31264157 | 0.83 | ALDH1A1 (0.56) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL2635853 | 0.83 | ALDH1A1 (0.56) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL2640650 | 0.76 | NOS3 (0.63) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL14635931 | 0.75 | KDR (0.49) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL4279542 | 0.75 | AR (0.42) | ARKDRIDH2 | |
| SCHEMBL3192275 | 0.73 | L3MBTL1 (0.55) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL2635471 | 0.72 | NR3C2 (0.47) | SORT1ALDH1A1GAAL3MBTL1AR | |
| SCHEMBL16637563 | 0.71 | KDR (0.55) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL16253003 | 0.71 | AR (0.58) | SORT1ALDH1A1GAAL3MBTL1RIOK2 | |
| SCHEMBL30875900 | 0.70 | NR3C2 (0.67) | SORT1ALDH1A1GAAL3MBTL1RIOK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TIE1, KDR, FLT1 | SORT1 3402/4885ALDH1A1 2646/4885GAA 4716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.