Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 15/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.62 |
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL989001 | 0.99 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9788804 | 0.89 | ADRA1D (0.57) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL15755823 | 0.88 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL10583793 | 0.78 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL800982 | 0.77 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL29387392 | 0.77 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL13532085 | 0.77 | POLB (0.60) | ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL989002 | 0.76 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9028670 | 0.74 | ADRA1D (0.70) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9028303 | 0.74 | ADRA1D (0.70) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034124-A2 | USE OF 5HT-1A-SEROTONINE RECEPTOR AGONISTS FOR TREATING GENETIC OR FUNCTIONAL RHYTHM DISORDERS IN THE RESPIRATORY SYSTEM | RICHTER DIETHELM WOLFGANG (DE) | 2001-05-17 | — | — | WO | claimed |
| JP-9169607-A | — | — | None | — | — | JP | disclosed |
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-06-04 | — | — | US | disclosed |
| JP-H09169607-A | ANTIFOULING AGENT CONTAINING ADRENERGIC ALPHA RECEPTOR-BLOCKING AGENT AS AN ACTIVE INGREDIENT | KAGAKU GIJUTSU SHINKO JIGYODAN | 1997-06-30 | — | — | JP | disclosed |
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| US-5030639-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-4980365-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-12-25 | — | — | US | disclosed |
| US-4957914-A | ANTIDEPRESSANTS, ANXIOLYTICS, HYPOTENSIVE AGENTS | SYNTEX (U.S.A.) INC. (US) | 1990-09-18 | — | — | US | disclosed |
| US-4305944-A | TRANQUILIZERS, NEUROLEPTIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PC, PCK2, CS | ADRA1D 3501/4885ADRA1A 2672/4885ADRA1B 3152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.