Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.49 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284732 | 0.83 | CYP26A1 (0.64) | CYP26A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13573931 | 0.78 | CYP26A1 (0.78) | CYP26A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10905859 | 0.77 | KCNN4 (0.50) | CYP26A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4284739 | 0.76 | CYP26A1 (0.65) | CYP26A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16503515 | 0.75 | CYP26A1 (0.47) | GABBR2GABBR1CYP26A1CYP1A2CYP3A4 | |
| SCHEMBL4284433 | 0.73 | ESR1 (0.44) | CYP26A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4278598 | 0.71 | ADRB2 (0.40) | CYP26A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5884820 | 0.71 | ALOX5 (0.56) | CYP1A2CYP2C9L3MBTL1LMNAMAPT | |
| SCHEMBL13448250 | 0.70 | CYP26A1 (0.37) | CYP26A1 | |
| SCHEMBL11276002 | 0.70 | MAPT (0.53) | MEN1KMT2AL3MBTL1PLA2G7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153566-A1 | CYP26 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009153566-A1 | CYP26 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |