Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CDC42 | P60953 | 1/20 | 0.48 |
| ▸ | RAC1 | P63000 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284732 | 0.88 | CYP26A1 (0.64) | CYP26A1CYP1A2CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL4278684 | 0.79 | CYP26A1 (1.00) | CYP26A1CYP1A2CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL4280477 | 0.76 | GABBR2 (0.49) | CYP26A1CYP1A2CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL30022351 | 0.75 | RAB9A (0.71) | CYP1A2CYP3A4AKR1C3AKR1C2MAPT | |
| SCHEMBL28900204 | 0.75 | RAB9A (0.71) | CYP1A2CYP3A4AKR1C3AKR1C2MAPT | |
| SCHEMBL5884820 | 0.75 | ALOX5 (0.56) | CYP1A2CYP2C9AKR1C3AKR1C2PTGS2 | |
| SCHEMBL9703849 | 0.73 | MAPT (0.55) | CYP26A1CYP1A2CYP3A4MAPTMTNR1B | |
| SCHEMBL15550406 | 0.72 | CYP26A1 (0.85) | CYP26A1CYP1A2CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL4285518 | 0.71 | CYP26A1 (0.67) | CYP26A1CYP1A2CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL4284433 | 0.71 | ESR1 (0.44) | CYP26A1CYP1A2CYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153566-A1 | CYP26 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009153566-A1 | CYP26 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |