Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304117 | 0.84 | BLM (0.39) | CYP26A1 | |
| SCHEMBL4284433 | 0.76 | ESR1 (0.44) | CYP26A1 | |
| SCHEMBL6393724 | 0.75 | CES2 (0.45) | CYP26A1 | |
| SCHEMBL4278598 | 0.74 | ADRB2 (0.40) | CYP26A1 | |
| SCHEMBL13345093 | 0.74 | HTR7 (0.42) | AKR1C3AKR1C2 | |
| SCHEMBL10905859 | 0.74 | KCNN4 (0.50) | CYP26A1MAPK1 | |
| SCHEMBL31560844 | 0.73 | CNR1 (0.54) | AKR1C3AKR1C2HDAC3HDAC1HDAC2 | |
| SCHEMBL23149887 | 0.73 | LMNA (0.37) | MAPK1AKR1C3AKR1C2 | |
| SCHEMBL4280477 | 0.70 | GABBR2 (0.49) | CYP26A1 | |
| SCHEMBL4285619 | 0.70 | ALDH1A1 (0.62) | CYP26A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168959-A1 | PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | Kyorin Pharmaceutical Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |