Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272582 | 0.91 | PTGDR2 (0.42) | KMT2AMEN1MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL4273827 | 0.88 | PTGDR2 (0.51) | RAB9AKMT2AMEN1MAPTHTT | |
| SCHEMBL4281914 | 0.81 | MTNR1A (0.40) | MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL4281837 | 0.80 | PTGDR2 (0.59) | RAB9AKMT2AMEN1CASRPTGDR2 | |
| SCHEMBL4275416 | 0.76 | PTGDR2 (0.60) | PTGDR2 | |
| SCHEMBL4268708 | 0.74 | KCNH2 (0.56) | MTNR1AMTNR1BCASRPTGDR2 | |
| SCHEMBL4266779 | 0.73 | MTNR1A (0.37) | ALDH1A1ADRB1MTNR1AMTNR1B | |
| SCHEMBL4273831 | 0.71 | PTGDR2 (0.61) | RAB9AKMT2AMEN1CASRPTGDR2 | |
| SCHEMBL4274289 | 0.71 | PTGDR2 (0.53) | PTGDR2 | |
| SCHEMBL4272589 | 0.71 | PTGDR2 (0.71) | RAB9AKMT2AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |