Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.36 |
| ▸ | HAT1 | O14929 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | GGT1 | P19440 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4271051 | 0.83 | L3MBTL1 (0.41) | ADRB2ADRB1L3MBTL1 | |
| SCHEMBL4275377 | 0.82 | MTNR1A (0.35) | MTNR1AMTNR1BALDH1A1GGT1 | |
| SCHEMBL4272582 | 0.81 | PTGDR2 (0.42) | MTNR1AMTNR1BHAT1EP300GGT1 | |
| SCHEMBL4274206 | 0.80 | HRH1 (0.36) | MTNR1AMTNR1BADRB2ADRB1HAT1 | |
| SCHEMBL4266788 | 0.74 | PTGDR2 (0.52) | ALDH1A1 | |
| SCHEMBL4281834 | 0.73 | RAB9A (0.42) | MTNR1AMTNR1BALDH1A1ADRB1 | |
| SCHEMBL4275189 | 0.73 | MTNR1A (0.42) | MTNR1AMTNR1BADRB2ADRB1 | |
| SCHEMBL4421324 | 0.71 | OXER1 (0.41) | ALDH1A1HAT1EP300TDP1L3MBTL1 | |
| SCHEMBL4424045 | 0.70 | MCL1 (0.48) | ALDH1A1 | |
| SCHEMBL10790278 | 0.70 | THRA (0.50) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |