Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | GGT1 | P19440 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281834 | 0.91 | RAB9A (0.42) | PTGDR2MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL4281914 | 0.87 | MTNR1A (0.40) | PTGDR2MTNR1AMTNR1BHAT1EP300 | |
| SCHEMBL4275416 | 0.84 | PTGDR2 (0.60) | PTGDR2 | |
| SCHEMBL4275377 | 0.84 | MTNR1A (0.35) | MTNR1AMTNR1BMEN1KMT2AGGT1 | |
| SCHEMBL4266779 | 0.81 | MTNR1A (0.37) | MTNR1AMTNR1BHAT1EP300GGT1 | |
| SCHEMBL4268708 | 0.79 | KCNH2 (0.56) | PTGDR2MTNR1AMTNR1B | |
| SCHEMBL4273827 | 0.78 | PTGDR2 (0.51) | PTGDR2MEN1KMT2A | |
| SCHEMBL4274289 | 0.78 | PTGDR2 (0.53) | PTGDR2F10FAAH | |
| SCHEMBL4274216 | 0.77 | PTGDR2 (0.52) | PTGDR2KMT2A | |
| SCHEMBL4272589 | 0.76 | PTGDR2 (0.71) | PTGDR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |