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Fluticasone Propionate

Fluticasone Propionate

SCHEMBL4281973

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluticasone Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 11/20 0.70
▸ PGR P06401 7/20 0.70
▸ CYP3A4 P08684 6/20 0.70
▸ AR P10275 4/20 0.70
▸ NR1I2 O75469 4/20 0.70
▸ ADORA3 P0DMS8 3/20 0.70
▸ NR3C2 P08235 2/20 0.70
▸ LMNA P02545 6/20 0.65
▸ MAPT P10636 3/20 0.65
▸ HIF1A Q16665 2/20 0.65
▸ HSD17B10 Q99714 1/20 0.65
▸ TDP1 Q9NUW8 1/20 0.65
▸ KDM4E B2RXH2 1/20 0.65
▸ MAPK1 P28482 1/20 0.65
▸ USP2 O75604 2/20 0.58
▸ MLNR O43193 1/20 0.58
▸ ABCB11 O95342 1/20 0.58
▸ CYP3A5 P20815 1/20 0.58
▸ PPARG P37231 1/20 0.58
▸ SMN1; SMN2 Q16637 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6685138 0.91 NR3C1 (0.63) NR3C1PGRCYP3A4ARNR1I2
Fluticasone Propionate SCHEMBL15568062 0.89 CYP3A4 (0.77) NR3C1PGRCYP3A4ARNR1I2
Fluticasone Propionate SCHEMBL1692016 0.88 NR3C1 (0.67) NR3C1PGRCYP3A4ARNR1I2
Betamethasone Dipropionate SCHEMBL3048282 0.86 NR3C1 (0.79) NR3C1PGRCYP3A4ARNR1I2
Fluocinonide SCHEMBL28188734 0.85 PGR (0.70) NR3C1PGRCYP3A4ARNR1I2
Fluocinolone Acetonide SCHEMBL5501859 0.85 HIF1A (0.77) NR3C1PGRCYP3A4ARNR1I2
Fluocinonide SCHEMBL11596245 0.84 NR3C1 (0.68) NR3C1PGRCYP3A4ARNR1I2
Fluticasone Propionate SCHEMBL9363101 0.84 NR3C1 (0.97) NR3C1PGRCYP3A4ARNR1I2
Fluticasone Propionate SCHEMBL9363108 0.84 NR3C1 (0.97) NR3C1PGRCYP3A4ARNR1I2
Fluticasone Propionate SCHEMBL15944858 0.84 NR3C1 (1.00) NR3C1PGRCYP3A4ARNR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005021722-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF NUCLEAR FACTOR κB THE JOHNS HOPKINS UNIVERSITY (US) 2005-03-10 — — WO claimed
US-8722613-B2 Methods and compositions for inhibition of nuclear factor kappaB THE JOHNS HOPKINS UNIVERSITY (US) 2014-05-13 — — US disclosed
US-20090099107-A1 Methods and Compositions for Inhibition of Nuclear Factor kappaB THE JOHNS HOPKINS UNIVERSITY (US) 2009-04-16 — — US disclosed
WO-2005021722-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF NUCLEAR FACTOR κB THE JOHNS HOPKINS UNIVERSITY (US) 2005-03-10 — — WO disclosed
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