Fluocinonide

SCHEMBL28188734

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nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.70

▸	PGR	P06401	8/20	0.70

▸	HIF1A	Q16665	7/20	0.70

▸	LMNA	P02545	6/20	0.70

▸	AR	P10275	4/20	0.70

▸	ALDH1A1	P00352	2/20	0.70

▸	MEN1	O00255	1/20	0.70

▸	KMT2A	Q03164	1/20	0.70

▸	CYP3A4	P08684	7/20	0.67

▸	MAPT	P10636	4/20	0.67

▸	USP2	O75604	3/20	0.67

▸	NR1I2	O75469	3/20	0.67

▸	ADORA3	P0DMS8	2/20	0.67

▸	SMN1; SMN2	Q16637	2/20	0.67

▸	NPSR1	Q6W5P4	2/20	0.67

▸	MLNR	O43193	1/20	0.67

▸	ABCB11	O95342	1/20	0.67

▸	CYP3A5	P20815	1/20	0.67

▸	PPARG	P37231	1/20	0.67

▸	CHRM1	P11229	1/20	0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluocinonide SCHEMBL11596245	0.90	NR3C1 (0.68)	PGRHIF1ANR3C1LMNAAR
Betamethasone Dipropionate SCHEMBL4286889	0.90	PGR (0.77)	PGRHIF1ANR3C1LMNAAR
SCHEMBL6685138	0.89	NR3C1 (0.63)	PGRHIF1ANR3C1LMNAAR
Halobetasol Propionate SCHEMBL28198190	0.88	PGR (0.67)	PGRHIF1ANR3C1LMNAAR
Betamethasone Dipropionate SCHEMBL18304670	0.88	PGR (0.82)	PGRHIF1ANR3C1LMNAAR
Halobetasol Propionate SCHEMBL1329604	0.88	NR3C1 (0.87)	PGRHIF1ANR3C1LMNAAR
Fluocinonide SCHEMBL3475945	0.86	HIF1A (0.75)	PGRHIF1ANR3C1LMNAAR
Fluocinonide SCHEMBL28122375	0.86	HIF1A (0.75)	PGRHIF1ANR3C1LMNAAR
Amcinonide SCHEMBL8420886	0.85	CYP3A4 (0.80)	PGRHIF1ANR3C1LMNAAR
Fluticasone Propionate SCHEMBL4281973	0.85	NR3C1 (0.70)	PGRHIF1ANR3C1LMNAAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-107405288-A	The polymer of itaconic acid and its purposes in cosmetic product or personal care product as film forming agent	伊塔康尼克（英国）有限公司	2017-11-28	—	—	CN	disclosed