Fluocinonide

SCHEMBL11596245

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nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.68

▸	HIF1A	Q16665	7/20	0.68

▸	PGR	P06401	7/20	0.68

▸	LMNA	P02545	6/20	0.68

▸	CYP3A4	P08684	5/20	0.68

▸	AR	P10275	3/20	0.68

▸	MEN1	O00255	2/20	0.68

▸	KMT2A	Q03164	2/20	0.68

▸	ALDH1A1	P00352	2/20	0.68

▸	USP2	O75604	2/20	0.68

▸	SMN1; SMN2	Q16637	1/20	0.61

▸	CYP1A2	P05177	1/20	0.61

▸	MAPT	P10636	3/20	0.61

▸	NR1I2	O75469	2/20	0.61

▸	HSD17B10	Q99714	1/20	0.61

▸	TDP1	Q9NUW8	1/20	0.61

▸	KDM4E	B2RXH2	1/20	0.61

▸	MAPK1	P28482	1/20	0.61

▸	CNR1	P21554	1/20	0.61

▸	KCNH2	Q12809	1/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluocinonide SCHEMBL28188734	0.90	PGR (0.70)	NR3C1HIF1APGRLMNACYP3A4
Betamethasone Valerate SCHEMBL8449742	0.89	NR3C1 (0.64)	NR3C1HIF1APGRLMNACYP3A4
Fluocinonide SCHEMBL28122375	0.88	HIF1A (0.75)	NR3C1HIF1APGRLMNACYP3A4
Fluocinonide SCHEMBL3475945	0.88	HIF1A (0.75)	NR3C1HIF1APGRLMNACYP3A4
SCHEMBL6685138	0.85	NR3C1 (0.63)	NR3C1HIF1APGRLMNACYP3A4
Fluticasone Propionate SCHEMBL4281973	0.84	NR3C1 (0.70)	NR3C1HIF1APGRLMNACYP3A4
Betamethasone Dipropionate SCHEMBL3048282	0.84	NR3C1 (0.79)	NR3C1HIF1APGRLMNACYP3A4
SCHEMBL3021332	0.84	NR3C1 (0.83)	NR3C1HIF1APGRLMNACYP3A4
SCHEMBL29438083	0.84	NR3C1 (0.83)	NR3C1HIF1APGRLMNACYP3A4
Fluocinonide SCHEMBL28089918	0.84	NR3C1 (0.94)	NR3C1HIF1APGRLMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4083974-A	Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether	THE UPJOHN COMPANY (US)	1978-04-11	—	—	US	claimed