Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TOP2A | P11388 | 2/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009430 | 0.84 | PTGS1 (0.34) | PTGS1LMNATOP2ATOP2BPIK3CD | |
| SCHEMBL4285918 | 0.71 | ALOX5 (0.38) | PTGS1LMNAALDH1A1KDM4ECYP2C19 | |
| SCHEMBL4285496 | 0.71 | TOP2A (0.34) | PTGS1LMNATOP2ATOP2BKMT2A | |
| SCHEMBL5597442 | 0.67 | CRBN (0.41) | LMNAKDM4ECYP2C19 | |
| SCHEMBL23513455 | 0.65 | PIK3CD (0.50) | PTGS1LMNATOP2ATOP2BPIK3CD | |
| SCHEMBL839300 | 0.64 | TOP2A (0.46) | PTGS1LMNATOP2ATOP2BPIK3CD | |
| SCHEMBL4621192 | 0.62 | PIK3CD (0.34) | PIK3CDKMT2A | |
| SCHEMBL2376601 | 0.62 | MAPT (0.45) | PTGS1LMNATOP2ATOP2BPIK3CD | |
| SCHEMBL1361476 | 0.59 | PIK3CD (0.33) | PIK3CD | |
| SCHEMBL19426510 | 0.59 | LMNA (0.48) | PTGS1LMNATOP2ATOP2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009157938-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER | CV THERAPEUTICS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |