Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5597442 | 0.71 | CRBN (0.41) | LMNACRBNKDM4ECYP2C19 | |
| SCHEMBL4284253 | 0.71 | PTGS1 (0.37) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL4283528 | 0.64 | DDB1 (0.46) | ALDH1A1MAPTTDP1PTGS1CRBN | |
| SCHEMBL5009430 | 0.63 | PTGS1 (0.34) | TOP2ATOP2BALDH1A1MAPTPTGS1 | |
| SCHEMBL23518791 | 0.61 | KDM4E (0.33) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL4291499 | 0.60 | KDM4E (0.31) | ALDH1A1MAPTKDM4E | |
| SCHEMBL378251 | 0.59 | TOP2A (0.50) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL5685558 | 0.59 | ALDH1A1 (0.33) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL12284503 | 0.58 | TOP2A (0.33) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL19426510 | 0.58 | LMNA (0.48) | TOP2ATOP2BALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009157938-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER | CV THERAPEUTICS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |