SCHEMBL4284446

SCHEMBL4284446

COc1ccc(C(=O)C2=C(Cl)CCCC2=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.53
MAPT P10636 4/20 0.47
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
KDM4E B2RXH2 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
THRB P10828 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
RECQL P46063 1/20 0.47
BLM P54132 1/20 0.47
MAPK1 P28482 3/20 0.45
RAB9A P51151 2/20 0.45
LMNA P02545 2/20 0.45
NPSR1 Q6W5P4 1/20 0.45
RXFP1 Q9HBX9 1/20 0.45
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
CA1 P00915 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4292937 0.84 ALDH1A1 (0.50) HPGDMAPTKMT2AMEN1KDM4E
SCHEMBL10192426 0.81 RAB9A (0.47) HPGDMAPTKMT2AKDM4ECYP1A2
SCHEMBL15133261 0.80 TPMT (0.37) MAPTKMT2AMEN1KDM4ECYP1A2
SCHEMBL10192812 0.80 ALDH1A1 (0.43) HPGDMAPTKMT2AMEN1RAB9A
SCHEMBL10192412 0.79 USP2 (0.45) HPGDMAPTKMT2AMEN1RAB9A
SCHEMBL4285306 0.77 HPGD (0.50) HPGDMAPTKMT2AMEN1MAPK1
SCHEMBL10192802 0.74 HTT (0.43) HPGDRAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL15133264 0.73 NAPRT (0.47) HPGDMAPTKMT2AMEN1RAB9A
SCHEMBL9418310 0.71 RXFP1 (0.79) HPGDMAPTKMT2AMEN1MAPK1
SCHEMBL51509 0.71 RXFP1 (0.79) HPGDMAPTKMT2AMEN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 HPGD 2655/4885MAPT 2884/4885KMT2A 1397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.