SCHEMBL4285306

SCHEMBL4285306

COc1ccc(C(=O)C2=C(Cl)CC(C)CC2=O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.50
KMT2A Q03164 2/20 0.44
LMNA P02545 3/20 0.44
MAPT P10636 3/20 0.43
RAB9A P51151 3/20 0.43
MAPK1 P28482 3/20 0.43
MEN1 O00255 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
CA1 P00915 3/20 0.40
CA2 P00918 3/20 0.40
ALDH1A1 P00352 2/20 0.40
GAA P10253 1/20 0.40
RAF1 P04049 1/20 0.39
GFER P55789 1/20 0.39
PAX8 Q06710 1/20 0.39
NPC1 O15118 2/20 0.39
TUBB4A P04350 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4285657 0.85 PARP10 (0.40) PARP10
SCHEMBL4288403 0.85 NPSR1 (0.46) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL4279762 0.84 LMNA (0.45) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL4284546 0.84 LMNA (0.45) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL4287147 0.83 LMNA (0.44) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL4283860 0.83 KMT2A (0.50) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL4284446 0.77 HPGD (0.53) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL10192404 0.71 ALDH1A1 (0.41) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL4288581 0.69 KMT2A (0.46) HPGDKMT2ALMNAMAPTRAB9A
SCHEMBL51509 0.69 RXFP1 (0.79) HPGDKMT2ALMNAMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 HPGD 2655/4885KMT2A 1397/4885LMNA 3975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.