SCHEMBL4292937

SCHEMBL4292937

COc1ccc(C(=O)C2=C(O)CCCC2=O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
MAPT P10636 4/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
KDM4E B2RXH2 1/20 0.48
CYP2D6 P10635 1/20 0.48
THRB P10828 1/20 0.48
RECQL P46063 1/20 0.48
BLM P54132 1/20 0.48
MAPK1 P28482 2/20 0.46
HPGD P15428 2/20 0.46
RAB9A P51151 2/20 0.46
LMNA P02545 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
NPC1 O15118 1/20 0.45
CES2 O00748 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4284446 0.84 HPGD (0.53) ALDH1A1MAPTMEN1KMT2ACYP1A2
SCHEMBL8588451 0.79 SMN1; SMN2 (0.54) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL4284546 0.77 LMNA (0.45) ALDH1A1MAPTMEN1KMT2AMAPK1
SCHEMBL51509 0.72 RXFP1 (0.79) ALDH1A1MAPTMEN1KMT2AMAPK1
SCHEMBL9418310 0.72 RXFP1 (0.79) ALDH1A1MAPTMEN1KMT2AMAPK1
SCHEMBL9803467 0.70 CA1 (0.50) ALDH1A1MAPTMEN1KMT2ACYP1A2
SCHEMBL19018122 0.69 MAPT (0.68) ALDH1A1MAPTMEN1KMT2AMAPK1
SCHEMBL1817437 0.69 MAPT (0.68) ALDH1A1MAPTMEN1KMT2AMAPK1
Ethyne SCHEMBL8195983 0.68 RXFP1 (0.73) ALDH1A1MAPTMEN1KMT2AMAPK1
SCHEMBL7041086 0.67 NPC1 (0.72) ALDH1A1MAPTMEN1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 ALDH1A1 896/4885MAPT 2884/4885MEN1 3776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.