Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CDC25B | P30305 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25C | P30307 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283372 | 0.81 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL4284732 | 0.80 | CYP26A1 (0.64) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4280423 | 0.78 | CYP26A1 (0.70) | CYP26A1CYP3A4ALDH1A1HPGDCYP1A2 | |
| SCHEMBL10905859 | 0.74 | KCNN4 (0.50) | CYP26A1CYP3A4ALDH1A1TSHRATM | |
| SCHEMBL4594357 | 0.74 | RAB9A (0.63) | RAB9ACYP3A4CDC25BALDH1A1TP53 | |
| SCHEMBL22250979 | 0.73 | ALDH1A1 (0.65) | CYP26A1RAB9ACYP3A4CDC25BALDH1A1 | |
| SCHEMBL29619354 | 0.72 | HSD17B10 (0.87) | RAB9ACYP3A4CDC25BALDH1A1TP53 | |
| SCHEMBL651572 | 0.72 | HSD17B10 (0.87) | RAB9ACYP3A4CDC25BALDH1A1TP53 | |
| SCHEMBL14048607 | 0.71 | RAB9A (0.58) | CYP26A1RAB9ACYP3A4CDC25BALDH1A1 | |
| SCHEMBL4284739 | 0.71 | CYP26A1 (0.65) | CYP26A1CYP3A4TSHRCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153566-A1 | CYP26 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009153566-A1 | CYP26 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |