Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285026 | 1.00 | LMNA (0.64) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27582258 | 0.89 | ALDH1A1 (0.56) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL31681471 | 0.88 | LMNA (0.55) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13761295 | 0.84 | ALDH1A1 (0.67) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL18767074 | 0.84 | POLB (0.68) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL18767075 | 0.84 | MAPT (0.57) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL513385 | 0.84 | ALDH1A1 (0.61) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8026101 | 0.83 | ALDH1A1 (0.65) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL18767073 | 0.81 | MAPT (0.54) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29018147 | 0.80 | CTSD (0.57) | LMNAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137681-A1 | Sirtuin Inhibiting Compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-05-28 | — | — | US | disclosed |
| US-20090137681-A1 | Sirtuin Inhibiting Compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-05-28 | — | — | US | disclosed |
| US-20090137681-A1 | Sirtuin Inhibiting Compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-05-28 | — | — | US | disclosed |
| WO-2007084162-A2 | SIRTUIN INHIBITING COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137681-A1 | Sirtuin Inhibiting Compounds | SIRT2, SIRT1, SIRT3 | LMNA 1961/4885MAPT 2630/4885MEN1 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.