Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL5065348 | 0.87 | ALDH1A1 (0.47) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL31530473 | 0.87 | ALDH1A1 (0.59) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL31530477 | 0.87 | ALDH1A1 (0.59) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL7475644 | 0.86 | GLA (0.53) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL7475632 | 0.86 | GLA (0.53) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL13761295 | 0.86 | ALDH1A1 (0.67) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL8026101 | 0.84 | ALDH1A1 (0.65) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL4285030 | 0.84 | LMNA (0.64) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL4285026 | 0.84 | LMNA (0.64) | ALDH1A1CTSDGLAKDM4EMAPT | |
| SCHEMBL15610552 | 0.83 | TDP1 (0.51) | ALDH1A1GLAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029015-A1 | Novel medical use of kynurenic acid, its precursors and derivatives | MARCINIAK ANDRZEJ (PL) | 2012-02-02 | — | — | US | disclosed |
| WO-2010110689-A1 | A NOVEL MEDICAL USE OF KYNURENIC ACID, ITS PRECURSORS AND DERIVATIVES | MARCINIAK ANDRZEJ (PL) | 2010-09-30 | — | — | WO | disclosed |
| EP-1294377-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALCOHOLISM AND ALCOHOL DEPENDENCE | Cardiff and Vale National Health Service Trust (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002002091-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALCOHOLISM AND ALCOHOL DEPENDENCE | CARDIFF & VALE NATIONAL HEALTH SERVICE TRUST (GB) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029015-A1 | Novel medical use of kynurenic acid, its precursors and derivatives | FFAR3, FFAR2, HCAR2 | ALDH1A1 3183/4885CTSD 1635/4885GLA 1666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.