Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285375 | 0.74 | HPGD (0.38) | CYP2B6EPHX2CHRM3GAASMN1; SMN2 | |
| SCHEMBL8827475 | 0.72 | CES1 (0.43) | GAA | |
| SCHEMBL4285382 | 0.71 | GAA (0.50) | EPHX2GAASMN1; SMN2LMNAHPGD | |
| SCHEMBL23903305 | 0.70 | ALDH1A1 (0.50) | EPHX2GAASMN1; SMN2LMNAHPGD | |
| SCHEMBL30608899 | 0.68 | CYP2B6 (0.43) | CYP2B6CHRM3MAPTMEN1KMT2A | |
| SCHEMBL9680992 | 0.67 | ALDH1A1 (0.51) | CYP2B6GAASMN1; SMN2LMNANPC1 | |
| SCHEMBL10634257 | 0.66 | CES1 (0.41) | EPHX2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL25442179 | 0.66 | KMT2A (0.45) | EPHX2GAASMN1; SMN2LMNAHPGD | |
| SCHEMBL11204803 | 0.66 | PPARG (0.46) | KDM4EMAPTMEN1KMT2APDK1 | |
| SCHEMBL9680403 | 0.65 | HPGD (0.52) | CYP2B6GAASMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069300-A2 | MULTIMEDIATOR TRANSPORTER INHIBITORS FOR USE IN TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PREXA PHARMACEUTICALS, INC. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008024371-A2 | MULTIMEDIATOR TRANSPORTER INHIBITORS FOR USE IN TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PREXA PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | disclosed |