Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23903305 | 0.82 | ALDH1A1 (0.50) | GAAEPHX2KMT2ASMN1; SMN2HPGD | |
| SCHEMBL29516647 | 0.77 | ALDH1A1 (0.51) | GAAKMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL25442179 | 0.77 | KMT2A (0.45) | GAAEPHX2KMT2ASMN1; SMN2HPGD | |
| SCHEMBL26059882 | 0.76 | PDK1 (0.43) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL25442490 | 0.73 | SMN1; SMN2 (0.42) | GAAEPHX2KMT2ASMN1; SMN2HPGD | |
| SCHEMBL22705629 | 0.72 | LMNA (0.56) | GAAKMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL4285371 | 0.71 | CYP2B6 (0.41) | GAAEPHX2KMT2ASMN1; SMN2HPGD | |
| SCHEMBL4285375 | 0.71 | HPGD (0.38) | GAAEPHX2KMT2ASMN1; SMN2HPGD | |
| SCHEMBL11656757 | 0.71 | PDK1 (0.52) | EPHX2KMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL30032441 | 0.70 | MLYCD (0.48) | KMT2AHPGDMEN1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069300-A2 | MULTIMEDIATOR TRANSPORTER INHIBITORS FOR USE IN TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PREXA PHARMACEUTICALS, INC. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008024371-A2 | MULTIMEDIATOR TRANSPORTER INHIBITORS FOR USE IN TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PREXA PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | disclosed |