SCHEMBL4287580

SCHEMBL4287580

COc1c(-c2ccccc2)oc2c(OS(=O)(=O)O)ccc(OC)c2c1=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 5/20 0.55
CTNNB1 P35222 5/20 0.55
ADORA3 P0DMS8 1/20 0.51
ABCB1 P08183 3/20 0.49
CYP1A1 P04798 3/20 0.49
CYP1B1 Q16678 3/20 0.49
CYP1A2 P05177 2/20 0.49
ABCG2 Q9UNQ0 4/20 0.47
KDM4E B2RXH2 3/20 0.47
MAPT P10636 3/20 0.47
GAA P10253 2/20 0.47
ALDH1A1 P00352 2/20 0.47
ABCC1 P33527 1/20 0.47
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46
TUBB3 Q13509 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30589558 0.80 ABCB1 (0.61) BCL9CTNNB1ADORA3ABCB1CYP1A1
SCHEMBL31065460 0.77 ALDH1A1 (0.68) BCL9CTNNB1ADORA3ABCB1ABCG2
SCHEMBL380907 0.75 ADORA3 (0.73) BCL9CTNNB1ADORA3ABCB1ABCG2
SCHEMBL1765292 0.74 ADORA3 (0.67) BCL9CTNNB1ADORA3ABCB1CYP1A1
SCHEMBL1764663 0.74 ABCG2 (0.66) BCL9CTNNB1ADORA3ABCB1CYP1A1
Water SCHEMBL4628870 0.73 ADORA3 (0.66) BCL9CTNNB1ADORA3ABCB1CYP1A1
SCHEMBL27783737 0.73 MAPT (0.73) BCL9CTNNB1ADORA3ABCB1CYP1A1
SCHEMBL4299053 0.73 KDM4E (0.65) BCL9CTNNB1ADORA3ABCB1CYP1A1
SCHEMBL29129504 0.73 CYP1A1 (0.53) BCL9CTNNB1ADORA3ABCB1CYP1A1
SCHEMBL4129003 0.72 MAPT (0.85) BCL9CTNNB1ADORA3ABCB1CYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009156040-A1 CONTAINER IMPERVIOUS TO OXYGEN AND CONTAINING AT LEAST ONE SELF TANNER MERCK PATENT GMBH (DE) 2009-12-30 WO disclosed
EP-2004136-A1 USE OF FLAVONOIDS Merck Patent GmbH (DE) 2008-12-24 EP disclosed
EP-1909919-A1 FLAVONOID IN THE FORM OF A SYNERGIST FOR ENHANCING A SELF-BROWNING SUBSTANCE EFFECT Merck Patent GmbH (DE) 2008-04-16 EP disclosed
WO-2007118565-A1 USE OF FLAVONOIDS MERCK PATENT GMBH (DE) 2007-10-25 WO disclosed
WO-2007012356-A1 FLAVONOID IN THE FORM OF A SYNERGIST FOR ENHANCING A SELF-BROWNING SUBSTANCE EFFECT MERCK PATENT GMBH (DE) 2007-02-01 WO disclosed