Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TEC | P42680 | 2/20 | 0.38 |
| ▸ | BMX | P51813 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4288326 | 0.92 | BTK (0.44) | BTKSIRT3TDP1BRD4PKMYT1 | |
| SCHEMBL27399023 | 0.76 | BTK (0.39) | BTKBRD4NUDT1PRKCQTLR7 | |
| SCHEMBL4768901 | 0.75 | NUDT1 (0.65) | BTKBRD4NUDT1PRKCQPAK1 | |
| SCHEMBL1694892 | 0.74 | RET (0.46) | BTKSIRT3TDP1BRD4NUDT1 | |
| SCHEMBL29499046 | 0.74 | RET (0.46) | BTKSIRT3TDP1BRD4NUDT1 | |
| SCHEMBL4770932 | 0.72 | NUDT1 (0.41) | BTKNUDT1PRKCQMAPK14TNK2 | |
| SCHEMBL27399123 | 0.70 | BTK (0.39) | BTKBRD4NUDT1PRKCQTLR7 | |
| SCHEMBL4813157 | 0.69 | JAK3 (0.51) | BTKJAK3TECSRCTNK2 | |
| SCHEMBL16382710 | 0.68 | BTK (0.53) | BTKSIRT3TDP1PKMYT1JAK3 | |
| SCHEMBL4665514 | 0.68 | PTGDR2 (0.42) | BTKSIRT3TDP1PKMYT1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080546-B2 | Pyrazolo-pyridinone derivatives and methods of use | AMGEN INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20090137582-A1 | Pyrazolo-pyridinone derivatives and methods of use | AMGEN INC. (US) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137582-A1 | Pyrazolo-pyridinone derivatives and methods of use | IL1B, IL1R1, IL1A | BTK 1160/4885SIRT3 757/4885TDP1 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.