Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29499046 | 0.81 | RET (0.46) | NUDT1CSNK1A1DYRK1BCHEK1BTK | |
| SCHEMBL1694892 | 0.81 | RET (0.46) | NUDT1CSNK1A1DYRK1BCHEK1BTK | |
| SCHEMBL4772891 | 0.79 | NUDT1 (1.00) | NUDT1CSNK1A1DYRK1BTYRO3BTK | |
| SCHEMBL4762982 | 0.79 | PRKCI (0.60) | NUDT1CHEK1PLK4AURKACSF1R | |
| SCHEMBL31409300 | 0.78 | METAP2 (0.55) | NUDT1CSNK1A1DYRK1BTYRO3CHEK1 | |
| SCHEMBL4770932 | 0.78 | NUDT1 (0.41) | NUDT1CSNK1A1DYRK1BCHEK1BTK | |
| SCHEMBL27872261 | 0.77 | NUDT1 (0.59) | NUDT1CSNK1A1DYRK1BTYRO3BCAT2 | |
| SCHEMBL4288326 | 0.76 | BTK (0.44) | NUDT1BTKTNK2PRKCQBRD4 | |
| SCHEMBL4768889 | 0.75 | NUDT1 (0.58) | NUDT1CSNK1A1DYRK1BTYRO3BCAT2 | |
| SCHEMBL28793917 | 0.75 | NUDT1 (0.51) | NUDT1CHEK1ROCK1PRKCQBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934181-A2 | KINASE INHIBITORS | Devgen NV (BE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | claimed |