Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770923 | 0.81 | CDC7 (0.38) | NUDT1BTKLTKCSNK1A1CDK5 | |
| SCHEMBL4768901 | 0.78 | NUDT1 (0.65) | NUDT1MAPK14BTKCHEK1ROCK1 | |
| SCHEMBL27740539 | 0.73 | KDM4E (0.47) | BTKCHEK1ROCK1PLK4MAP4K4 | |
| SCHEMBL4288319 | 0.72 | BTK (0.43) | NUDT1MAPK14BTKTNK2PRKCQ | |
| SCHEMBL4288326 | 0.71 | BTK (0.44) | NUDT1BTKTNK2SYKPRKCQ | |
| SCHEMBL29499046 | 0.70 | RET (0.46) | NUDT1BTKCHEK1ROCK1PLK4 | |
| SCHEMBL1694892 | 0.70 | RET (0.46) | NUDT1BTKCHEK1ROCK1PLK4 | |
| SCHEMBL17237437 | 0.70 | SIRT3 (0.51) | MAPK14BTKCHEK1AURKARET | |
| SCHEMBL27399023 | 0.67 | BTK (0.39) | NUDT1BTKROCK1SYKPRKCQ | |
| SCHEMBL3559657 | 0.67 | ALDH1A1 (0.54) | BTKCSNK1A1DYRK1BKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934181-A2 | KINASE INHIBITORS | Devgen NV (BE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | claimed |