Sugi Predict

Sugi Predict / Compounds / Bromide

Bromide

Bromide

SCHEMBL4288442

COc1ccc(O)c(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-]

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE known ✓ P22303 1/20 0.40
▸ GAA P10253 3/20 0.47
▸ LMNA P02545 3/20 0.47
▸ MTNR1A P48039 1/20 0.45
▸ MTNR1B P49286 1/20 0.45
▸ TSHR P16473 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ RAB9A P51151 2/20 0.43
▸ CA1 P00915 2/20 0.43
▸ CA2 P00918 2/20 0.43
▸ PKM P14618 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ MAPT P10636 2/20 0.43
▸ HPGD P15428 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8798184 0.97 GAA (0.47) GAALMNAMTNR1AMTNR1BTSHR
Bromide SCHEMBL1681292 0.88 POLB (0.50) GAALMNATSHRPOLBNPC1
Bromide SCHEMBL7804211 0.83 HTR2A (0.54) TSHRCA1CA2KDM4EMEN1
Bromide SCHEMBL5444015 0.82 HTR1A (0.43) GAALMNAMTNR1B
Bromide SCHEMBL5419484 0.82 SLC6A4 (0.43) MEN1KMT2ATDP1CYP1A2SLC6A2
Bromide SCHEMBL16555986 0.80 KDM1A (0.45) GAATSHRMEN1KMT2ACYP1A2
Bromide SCHEMBL8797860 0.79 CALM1 (0.38) POLBALDH1A1KDM4EMEN1MAPT
Bromide SCHEMBL15266086 0.79 HMGCR (0.50) TSHRCA1CA2ALDH1A1KDM4E
Bromide SCHEMBL1681703 0.79 MMP1 (0.38) TSHRCYP1A2
Bromide SCHEMBL5828503 0.79 SLC6A4 (0.41) TSHRCYP1A2SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090253687-A1 Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-10-08 — — US disclosed
US-5693807-A Substituted hydroquinone derivatives CIBA-GEIGY CORPORATION (US) 1997-12-02 — — US disclosed
EP-0542671-B1 Substituted hydroquinone derivatives as intermediates of benzofuran derivatives CIBA GEIGY AG (CH) 1997-01-02 — — EP disclosed
US-5290939-A Process for the manufacture of brofaromine and analogs thereof CIBA-GEIGY CORPORATION (US) 1994-03-01 — — US disclosed
EP-0542671-A1 Substituted hydroquinone derivatives as intermediates of benzofuran derivatives CIBA-GEIGY AG (CH) 1993-05-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253687-A1 Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands NR3C2, NR3C1, MC2R ACHE 3984/4885GAA 4763/4885LMNA 2152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.