Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285848 | 0.92 | SLC6A2 (0.42) | TSHRMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4292808 | 0.92 | SLC6A3 (0.45) | SLC6A2SLC6A4SLC6A3HTT | |
| SCHEMBL4291881 | 0.87 | SLC6A3 (0.40) | MAPTSLC6A2SLC6A4SLC6A3HSD11B1 | |
| SCHEMBL4280118 | 0.85 | HTR2A (0.40) | HSD11B1 | |
| SCHEMBL4291623 | 0.84 | HCRTR2 (0.41) | HSD11B1L3MBTL1RAB9A | |
| SCHEMBL4294068 | 0.83 | POLB (0.36) | TSHRMAPTHSD11B1SMN1; SMN2 | |
| SCHEMBL4285491 | 0.80 | KMT2A (0.41) | SLC6A2SLC6A4SLC6A3HTTSMN1; SMN2 | |
| SCHEMBL4288939 | 0.80 | TSHR (0.44) | TSHRMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4282511 | 0.79 | HSD17B10 (0.46) | TSHRLMNAHTTSMN1; SMN2 | |
| SCHEMBL4282253 | 0.75 | TACR1 (0.41) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009072643-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-11 | — | — | WO | disclosed |