SCHEMBL4292103

SCHEMBL4292103

C=Cc1ccccc1OC(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 1/20 0.41
PTGES2 Q9H7Z7 1/20 0.40
ALDH1A1 P00352 3/20 0.40
GAA P10253 1/20 0.38
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
TRPA1 O75762 2/20 0.36
HCAR1 Q9BXC0 2/20 0.35
HSD11B1 P28845 1/20 0.34
MPL P40238 1/20 0.34
TRPM8 Q7Z2W7 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2B Q13224 1/20 0.34
ANO1 Q5XXA6 1/20 0.34
EPHX2 P34913 1/20 0.33
FFAR1 O14842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24517871 0.83 PTGES2 (0.40) CCR3PTGES2ALDH1A1GAARXRA
SCHEMBL16958972 0.82 PTGES2 (0.35) CCR3PTGES2ALDH1A1GAATRPA1
SCHEMBL16955643 0.82 CCR3 (0.33) CCR3PTGES2ALDH1A1GAATRPA1
SCHEMBL16954424 0.82 MPL (0.41) CCR3PTGES2ALDH1A1GAATRPA1
SCHEMBL16962789 0.81 NFE2L2 (0.35) CCR3PTGES2GAAHCAR1HSD11B1
SCHEMBL16953329 0.81 ALDH1A1 (0.39) CCR3PTGES2ALDH1A1GAAL3MBTL1
SCHEMBL16952006 0.81 CCR3 (0.33) CCR3PTGES2ALDH1A1GAATRPA1
SCHEMBL1044650 0.80 PTGES2 (0.45) CCR3PTGES2ALDH1A1GAARXRA
SCHEMBL1044649 0.80 PTGES2 (0.45) CCR3PTGES2ALDH1A1GAARXRA
Formaldehyde SCHEMBL27526817 0.80 ALDH1A1 (0.52) CCR3PTGES2ALDH1A1GAARXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110330535-A N-heterocyclic carbine base mixed matching nickel (II) complex and its application 苏州大学 2019-10-15 CN claimed
CN-110330535-A N-heterocyclic carbine base mixed matching nickel (II) complex and its application 苏州大学 2019-10-15 CN disclosed
CN-106336349-B Bromo trifluoromethoxy compound and its synthetic method 南京优氟医药科技有限公司 2019-08-02 CN disclosed
CN-106336349-A Bromotrifluoromethoxy compound and synthetic method thereof 南开大学 2017-01-18 CN disclosed
US-20090227560-A1 Substituted imidazole compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-09-10 US disclosed
CN-100412161-C Liquid crystal aligning agent and liquid crystal display element JSR CORP (JP) 2008-08-20 CN disclosed
CN-100344731-C Liquid crystal aligning agent and liquid crystal display element JSR CORP (JP) 2007-10-24 CN disclosed
CN-1721502-A Liquid crystal aligning agent and liquid crystal display element JSR CORP (JP) 2006-01-18 CN disclosed
US-6673523-B2 APPLYING PHOTORESIST FILM TO SEMICONDUCTOR SUBSTRATE; IRRADIATION; DEVELOPMENT MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 2004-01-06 US disclosed
CN-1408817-A Liquid crystal aligning agent and liquid crystal display element JSR CORP (JP) 2003-04-09 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227560-A1 Substituted imidazole compound and use thereof REN, ACE, AGT CCR3 4507/4885PTGES2 985/4885ALDH1A1 388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.