Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9802774 | 0.81 | HPD (0.41) | MAPTCYP1A2MEN1CYP2D6CYP2C19 | |
| SCHEMBL4292937 | 0.70 | ALDH1A1 (0.50) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL4284446 | 0.69 | HPGD (0.53) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL201761 | 0.68 | PARP10 (1.00) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL10925317 | 0.67 | CA1 (0.67) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL13207340 | 0.67 | TDP1 (0.75) | MAPTCYP1A2CYP2C9CYP2C19BLM | |
| Hydrochloric Acid SCHEMBL408766 | 0.66 | PARP10 (0.95) | CA1CA2PARP10PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL4376056 | 0.66 | PARP10 (0.95) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL16936986 | 0.66 | MAOA (0.55) | CA1CA2MAPTKDM4ECYP1A2 | |
| SCHEMBL15708391 | 0.65 | CA1 (0.69) | CA1CA2PARP10PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068334-A | Analgesics and antipyretics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |