Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161504 | 0.83 | GPR119 (0.46) | HCAR1GPR119CLK2CLK3GSK3B | |
| SCHEMBL4169160 | 0.76 | GPR119 (0.46) | HCAR1GPR119 | |
| SCHEMBL4297154 | 0.76 | PRPS1 (0.42) | DPP4GPR119IDO1 | |
| SCHEMBL31588731 | 0.70 | DPP4 (0.37) | DPP4GPR119CLK2CLK3GSK3B | |
| SCHEMBL14851772 | 0.69 | MAPT (0.47) | GPR119 | |
| SCHEMBL5780128 | 0.69 | FGFR1 (0.36) | HCAR1 | |
| SCHEMBL30441999 | 0.69 | FGFR1 (0.36) | HCAR1 | |
| SCHEMBL28689236 | 0.69 | POLB (0.39) | DYRK1ACLK4DYRK1B | |
| SCHEMBL24752971 | 0.68 | GPR119 (0.42) | HCAR1DPP4GPR119 | |
| SCHEMBL30120002 | 0.68 | GPR119 (0.42) | HCAR1DPP4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079001-A1 | BICYCLIC HETEROARYL-SUBSTITUTED IMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-25 | — | — | WO | disclosed |