SCHEMBL4294644

SCHEMBL4294644

COC(=O)CCCC(F)F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.61
LMNA P02545 4/20 0.44
ALDH1A1 P00352 2/20 0.44
KMT2A Q03164 4/20 0.43
MEN1 O00255 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
GLA P06280 1/20 0.42
SLC1A1 P43005 1/20 0.39
CA12 O43570 1/20 0.39
CA14 Q9ULX7 1/20 0.39
KDM4E B2RXH2 1/20 0.39
RECQL P46063 1/20 0.39
HSD17B10 Q99714 2/20 0.38
OXER1 Q8TDS5 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
MGAM O43451 1/20 0.37
GAA P10253 1/20 0.37
SI P14410 1/20 0.37
MGAM2 Q2M2H8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14140994 0.86
SCHEMBL12562841 0.85 TSHR (0.43) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL25981499 0.84 TSHR (0.58) TSHRLMNAALDH1A1KMT2AMEN1
Hydrochloric Acid SCHEMBL27984353 0.84 TSHR (0.55) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL7183546 0.81 TSHR (0.54) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL7783582 0.81 TSHR (0.54) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL130826 0.79 TSHR (0.64) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL8432394 0.79 TSHR (0.64) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL27547594 0.78 TSHR (0.56) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL7184542 0.78 TSHR (0.56) TSHRLMNAALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230261263-A1 ELECTROLYTIC SOLUTION, ELECTROCHEMICAL DEVICE, AND ELECTRONIC DEVICE DONGGUAN AMPEREX TECHNOLOGY LIMITED (CN) 2023-08-17 US disclosed
EP-4207423-A1 ELECTROLYTE, ELECTROCHEMICAL DEVICE AND ELECTRONIC DEVICE Dongguan Amperex Technology Limited (CN) 2023-07-05 EP disclosed
EP-2061470-A2 HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES Neurogen Corporation (US) 2009-05-27 EP disclosed
US-20080090845-A1 Haloalkyl-substituted pyrimidinone derivatives NEUROGEN CORPORATION (US) 2008-04-17 US disclosed
US-20080090845-A1 Haloalkyl-substituted pyrimidinone derivatives NEUROGEN CORPORATION (US) 2008-04-17 US disclosed
US-20080090845-A1 Haloalkyl-substituted pyrimidinone derivatives NEUROGEN CORPORATION (US) 2008-04-17 US disclosed
WO-2008024433-A2 HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES NEUROGEN CORPORATION (US) 2008-02-28 WO disclosed
WO-2008024433-A2 HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES NEUROGEN CORPORATION (US) 2008-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080090845-A1 Haloalkyl-substituted pyrimidinone derivatives PIGS, GPR174, GPR17 TSHR 119/4885LMNA 3157/4885ALDH1A1 461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.