Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285713 | 0.79 | EGFR (0.70) | ACLYALDH1A1EGFRFGFR1KDR | |
| SCHEMBL4287231 | 0.79 | NR1I2 (0.56) | ALDH1A1NR1I2TSHRPOLBGAA | |
| SCHEMBL4281632 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KEAP1NFE2L2TSHRPOLB | |
| SCHEMBL4294795 | 0.78 | ACLY (0.53) | ACLYALDH1A1EGFRFGFR1KDR | |
| SCHEMBL812919 | 0.77 | TSHR (0.70) | ALDH1A1TSHRPOLBGAAGFER | |
| SCHEMBL31679946 | 0.76 | PKM (0.55) | ACLYEGFRFGFR1KDRPOLB | |
| SCHEMBL4291216 | 0.70 | KDR (0.47) | ACLYALDH1A1EGFRFGFR1KDR | |
| SCHEMBL21999774 | 0.70 | ACLY (1.00) | ACLYEGFRFGFR1KDR | |
| SCHEMBL19248968 | 0.69 | GAA (0.53) | ACLYEGFRFGFR1KDRTSHR | |
| SCHEMBL19329741 | 0.69 | EGFR (0.53) | ACLYALDH1A1EGFRFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | ACLY 2320/4885ALDH1A1 694/4885EGFR 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.