Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | TAS2R8 | Q9NYW2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.47 |
| ▸ | SCD | O00767 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12539515 | 0.81 | MEN1 (0.53) | NR1I2TAS2R8ALDH1A1CA1L3MBTL1 | |
| SCHEMBL4282959 | 0.81 | TAS2R8 (0.63) | TAS2R8ALDH1A1L3MBTL1SCD5SCD | |
| SCHEMBL23389286 | 0.80 | TAS2R8 (0.48) | TAS2R8ALDH1A1GAATSHRSCD5 | |
| SCHEMBL4282988 | 0.79 | HDAC3 (0.51) | TAS2R8ALDH1A1L3MBTL1SCD5SCD | |
| SCHEMBL4294936 | 0.79 | ACLY (0.54) | NR1I2ALDH1A1POLBGAATSHR | |
| SCHEMBL4281646 | 0.76 | KMT2A (0.50) | TAS2R8ALDH1A1L3MBTL1SCD5SCD | |
| SCHEMBL4281632 | 0.75 | ALDH1A1 (0.54) | ALDH1A1CA1POLBGAATSHR | |
| SCHEMBL812919 | 0.74 | TSHR (0.70) | ALDH1A1CA1L3MBTL1POLBGAA | |
| SCHEMBL4279784 | 0.73 | AR (0.51) | TAS2R8ALDH1A1L3MBTL1SCD5SCD | |
| SCHEMBL19223061 | 0.72 | L3MBTL1 (0.57) | TAS2R8ALDH1A1L3MBTL1SCD5SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | NR1I2 98/4885TAS2R8 4508/4885ALDH1A1 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.