Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 1/20 | 0.55 |
| ▸ | CTSC | P53634 | 1/20 | 0.55 |
| ▸ | CPT2 | P23786 | 2/20 | 0.52 |
| ▸ | CPT1A | P50416 | 2/20 | 0.52 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952780 | 0.88 | CTSL (0.70) | CTSLCTSSCTSKCTSCL3MBTL1 | |
| SCHEMBL3946155 | 0.88 | CTSL (0.52) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL13663720 | 0.88 | CTSL (0.52) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL3948831 | 0.87 | CTSL (0.55) | CTSLCTSSCTSKCTSCWDR5 | |
| SCHEMBL3948813 | 0.87 | ACHE (0.43) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL4294636 | 0.86 | CPT2 (0.51) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL3945737 | 0.83 | CTSL (0.79) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL4290366 | 0.82 | CPT2 (0.48) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL4298295 | 0.80 | CPT2 (0.50) | CTSLCTSSCTSKCTSCCPT2 | |
| SCHEMBL3815610 | 0.80 | CPT2 (0.65) | CTSLCTSSCTSKCTSCCPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264431-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264431-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | CTSB, CTSS, CTSF | CTSL 7/4885CTSS 2/4885CTSK 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.