Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.42 |
| ▸ | DHFR | P00374 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4301098 | 0.77 | TLR7 (0.36) | TLR7TLR8 | |
| SCHEMBL5410261 | 0.76 | TLR8 (0.46) | TLR7TLR8 | |
| SCHEMBL5410266 | 0.72 | TLR7 (0.43) | TLR7TLR8 | |
| SCHEMBL4753166 | 0.65 | TLR8 (0.48) | TLR7TLR8 | |
| SCHEMBL20134736 | 0.65 | DHFR (0.67) | DHFR | |
| SCHEMBL6807516 | 0.64 | PI4KA (0.41) | TLR7TLR8DHFR | |
| SCHEMBL18587594 | 0.64 | TLR7 (0.75) | TLR7TLR8 | |
| SCHEMBL18109747 | 0.64 | DHFR (0.69) | DHFR | |
| SCHEMBL3863988 | 0.63 | TLR7 (0.81) | TLR7TLR8 | |
| Hydrochloric Acid SCHEMBL30503496 | 0.63 | TLR7 (0.79) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270443-A1 | 1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270443-A1 | 1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS | IL2, IL4I1, IFNG | TLR7 188/4885TLR8 208/4885DHFR 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.