Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487054 | 0.84 | KMT2A (0.41) | NTRK1PIM1GAAMEN1KMT2A | |
| SCHEMBL4307232 | 0.80 | NR1H2 (0.43) | SCN9ASCN10ANTRK1PIM1GAA | |
| SCHEMBL4302003 | 0.73 | SCN9A (0.50) | SCN9ASCN10ACYP2C9CYP3A4CYP2D6 | |
| SCHEMBL28207099 | 0.72 | SCN9A (0.42) | SCN9ASCN10ANTRK1PIM1GAA | |
| SCHEMBL6676513 | 0.72 | SCN9A (0.41) | SCN9ASCN10ACYP2C9CYP3A4CYP2D6 | |
| SCHEMBL27855040 | 0.72 | SCN9A (0.46) | SCN9ASCN10AGAAMEN1KMT2A | |
| SCHEMBL2462564 | 0.68 | SMN1; SMN2 (0.41) | GAAKMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL2824267 | 0.66 | ALDH1A1 (0.48) | SCN9AGAAMEN1KMT2AKDM4E | |
| SCHEMBL6024428 | 0.66 | ESR1 (0.51) | SCN9AGAAMEN1KMT2ACYP3A4 | |
| SCHEMBL4301998 | 0.66 | SCN9A (0.47) | SCN9ASCN10ACYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | SCN9A 2437/4885SCN10A 1733/4885NTRK1 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.