Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539918 | 1.00 | HPGD (0.53) | HPGDSMN1; SMN2POLBTYK2KDM4E | |
| SCHEMBL10725375 | 0.85 | HPGD (0.56) | HPGDSMN1; SMN2POLBTYK2KDM4E | |
| SCHEMBL13397914 | 0.81 | HPGD (0.56) | HPGDSMN1; SMN2POLBTYK2KDM4E | |
| SCHEMBL21616491 | 0.81 | RAB9A (0.62) | HPGDSMN1; SMN2POLBKDM4ENPC1 | |
| SCHEMBL16358839 | 0.79 | HPGD (0.55) | HPGDSMN1; SMN2POLBTYK2KDM4E | |
| SCHEMBL14786453 | 0.79 | HPGD (0.55) | HPGDSMN1; SMN2POLBTYK2KDM4E | |
| SCHEMBL6597631 | 0.79 | HPGD (0.55) | HPGDSMN1; SMN2POLBTYK2KDM4E | |
| SCHEMBL18586565 | 0.79 | POLB (0.35) | HPGDSMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL482540 | 0.78 | HPGD (0.53) | HPGDSMN1; SMN2POLBTYK2NPC1 | |
| SCHEMBL11663064 | 0.76 | HPGD (0.54) | HPGDSMN1; SMN2POLBTYK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482449-B2 | Process for making spirolactone compounds | MERCK & CO., INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20080171888-A1 | Process for making spirolactone compounds | MERCK SHARP & DOHME CORP. | 2008-07-17 | — | — | US | disclosed |
| US-7368569-B2 | Process for making spirolactone compounds | MERCK & CO., INC. (US) | 2008-05-06 | — | — | US | disclosed |
| CN-1894256-A | Process for preparing spirolactone compounds | MERCK & CO INC (US) | 2007-01-10 | — | — | CN | disclosed |
| US-20060241299-A1 | Process for making spirolactone compounds | VOLANTE RALPH P | 2006-10-26 | — | — | US | disclosed |
| US-20060014950-A1 | Process for Making Spirolactone Compounds | MERCK SHARP & DOHME CORP. | 2006-01-19 | — | — | US | disclosed |
| EP-1558605-A2 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004104009-A1 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| WO-2004037170-A2 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | MERCK & CO., INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| WO-1993014086-A1 | SUBSTITUTED 1-ISOQUINOLONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241299-A1 | Process for making spirolactone compounds | HSD17B7, SDHB, SDHA | HPGD 756/4885SMN1; SMN2 1700/4885POLB 2615/4885 |
| US-20080171888-A1 | Process for making spirolactone compounds | HSD17B7, CYP17A1, REN | HPGD 126/4885SMN1; SMN2 3962/4885POLB 2406/4885 |
| US-20060014950-A1 | Process for Making Spirolactone Compounds | HSD17B7, CYP17A1, REN | HPGD 126/4885SMN1; SMN2 3962/4885POLB 2406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.