Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313656 | 0.84 | TDP1 (0.51) | ALDH1A1KDM4EMAPTSMN1; SMN2TDP1 | |
| SCHEMBL4302329 | 0.83 | ACHE (0.42) | ALDH1A1KDM4EMAPTSMN1; SMN2TDP1 | |
| SCHEMBL1557626 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTHDAC1HDAC6HTR1A | |
| SCHEMBL4310271 | 0.80 | ALDH1A1 (0.41) | ALDH1A1MAPTTDP1MAPK14L3MBTL1 | |
| SCHEMBL22864631 | 0.78 | NR4A2 (0.54) | ALDH1A1KDM4ENR4A2MEN1TP53 | |
| SCHEMBL29800593 | 0.78 | NR4A2 (0.54) | ALDH1A1KDM4ENR4A2MEN1TP53 | |
| SCHEMBL24243751 | 0.75 | KDM4E (0.50) | ALDH1A1KDM4E | |
| SCHEMBL30877215 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTHTR1AACHE | |
| SCHEMBL24243752 | 0.73 | HTR2A (0.48) | ALDH1A1KDM4E | |
| SCHEMBL25311099 | 0.73 | KDM4E (0.48) | ALDH1A1KDM4ESMN1; SMN2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |